Launched in 2017, Planning for Regenerative, Equitable Food Systems in Urbanizing Global Environments (Plan-REFUGE) aspires to understand and mitigate food inequities experienced by smallholder farmers in the Global South. Using a transdisciplinary approach, we investigate how small-holder farmers in the Global South adapt their daily living practices (DLPs) in the face of a number of challenges including globalization and climate change. Lessons from on-the-ground experiences are used to inform purposeful community development and planning strategies. The project ensures a Global South-to-Global South learning exchange as well as capacity-building of policy makers both locally and globally through publications and trainings. Plan-REFUGE is a collaborative effort that includes the Indian states of Kerala and Odisha; the Parish of Clarendon, Jamaica, and the city of Accra, Ghana. This work is supported by the University at Buffalo’s Community of Excellence in Global Health Equity.